But according to Sci-Fi wire a script for SM 4 is coming and Raimi hopes to direct it, if he likes the script. He says he wouldn't want to recast Mary Jane or Peter Parker. The problem is I'm not sure either of them want to be in another Spider-Man movie.
While I think that Spider-Man translates well to the screen and has a world of great stories to tell, I think there should be a break. Let people enjoy some other movies for a while. Then come back in 5 or 8 years and do some more with the character.