According to the 'rama column, it will have a Civil War theme. In fact, it will go from Secret War into Civil War, with some shortening of stories and slight revisions so that we can have Hulk and Thor in the game.
And new game play, "In addition to the confirmed longer, more directly-comics-based storyline, players will have a dynamic conversation system, with choices between “aggressive, defensive, or diplomatic” responses during conversation. Each style will take your team in a different direction. Similar to the team power-ups from the first game, new rewards will come your way depending on how you treat non playable characters. These will not be dependent on a set number of characters, either. You can use any playable characters at any time without losing any of your earned power-ups."
Confirmed characters so far are: Captain America, Spider-Man, Wolverine, Luke Cage, Daredevil, Thor, Thing, Human Torch, Invisible Woman, Mr. Fantastic, Hulk, and Iron Man, with more to come, as the game maker promises over 20 characters to be in the game.
Activision will have a booth at San Diego Comic Con this weekend, so there may be even more news on this game coming up.
I'm excited about this game. We played the first one and it was pretty cool. This new one sounds even better, and now that we have a "next gen" machine we should have access to even more characters. I'm almost tempted to find the cheat codes that will allow us to access all the characters right away.